Isotopically Labeled Compounds
Medchemexpress LLC Pimozide-d4-1 | 2062-78-4 | 1 MG
Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM. Additionally, Pimozide inhibits STAT3 and STAT5.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Cholesterol-d6-1 | 92543-08-3 | 99.82% | 392.69 | 1 MG
Cholesterol-d6-1 is deuterium labeled Cholesterol, a primary sterol in mammals that makes up 20-25% of the plasma membrane's structural component. It plays a significant role in determining the fluidity and permeability characteristics of the membrane, as well as the function of transporters and signaling proteins. It also acts as an endogenous estrogen-related receptor α (ERRα) agonist.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Pitavastatin-d4 sodium | 574705-92-3 | 99.7% | 1 MG
Pitavastatin-d4 sodium is a deuterium-labeled version of Pitavastatin sodium. Deuteration, the process of incorporating stable heavy isotopes of hydrogen (deuterium) into drug molecules, has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Amlodipine-d4 | 1185246-14-3 | 98.5% | 5 MG
Amlodipine-d4 is a deuterium labeled Amlodipine. Amlodipine is an antianginal agent and an orally active dihydropyridine calcium channel blocker. It functions by blocking voltage-dependent L-type calcium channels, which inhibits the initial influx of calcium. Amlodipine can be utilized for the research of high blood pressure and cancer.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Terazosin-d8 | 1006718-20-2 | 99.2% | 2.5 MG
Terazosin-d8 is a deuterium-labeled quinazoline derivative and a competitive, orally active α1-adrenoceptor antagonist. It functions by relaxing blood vessels and opening the bladder, making it suitable for potential applications in treating benign prostatic hyperplasia (BPH) and high blood pressure. Deuteration influences the pharmacokinetic and metabolic profiles of drugs.
- Competitive and orally active α1-adrenoceptor antagonist
- Relaxes blood vessels and opens the bladder
- Potential for benign prostatic hyperplasia (BPH) treatment
- Potential for high blood pressure treatment
- Can be used as a tracer or an internal standard
- Suitable for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC DL-Tryptophan-d3 | 340257-61-6 | 99.3% | 207.24 | 25 MG
DL-Tryptophan-d3 is the deuterium labeled DL-Tryptophan, an endogenous metabolite for research use only. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Contains stable heavy isotopes of hydrogen, carbon, and other elements.
- Potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Memantine-d6 (hydrochloride) | 1189713-18-5 | 99.8% | 500 UG
Memantine-d6 (hydrochloride) is a deuterium labeled Memantine hydrochloride. It functions as a moderate affinity, uncompetitive NMDA receptor antagonist, inhibiting CYP2B6 and CYP2D6. This compound is intended for research use only, primarily as a tracer and internal standard for quantitative analysis. Deuteration, involving the incorporation of stable heavy isotopes into drug molecules, is utilized for quantitation during drug development and may influence pharmacokinetic and metabolic profiles.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes incorporated into drug molecules.
- Deuteration has the potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Pimozide-d4-1 | 2062-78-4 | 100 UG
Pimozide-d4-1 is a deuterium-labeled version of Pimozide, a dopamine receptor antagonist. It exhibits Ki values of 1.4 nM for D2, 2.5 nM for D3, and 588 nM for D1 receptors, along with affinity at the α1-adrenoceptor (Ki of 39 nM). Additionally, Pimozide inhibits STAT3 and STAT5. Deuterium labeling allows for its use as a tracer and internal standard in quantitative analyses, impacting pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labeled compound
- Functions as a dopamine receptor antagonist
- Exhibits affinity at α1-adrenoceptor
- Inhibits STAT3 and STAT5
- Useful as a tracer in drug development
- Serves as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Impacts pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Taurine-13C2 | 70155-54-3 | MFCD01075566 | 99.9% | 5 MG
Taurine-13C2 is a 13C-labeled form of Taurine, a sulfur-containing amino acid and organic osmolyte. It plays a role in cell volume regulation, serves as a substrate for bile salt formation, and modulates intracellular free calcium concentration. Taurine has also been shown to activate autophagy in adipocytes.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Molecular weight: 127.13
- Isotopic purity: ≥99 atom % 13C
- Assay: ≥98% (CP)
- Mass shift: M+2
- Physical form: solid
- Suitable for bio NMR and mass spectrometry (MS) techniques
- Melting point: >300 °C
Medchemexpress LLC Erythromycin-d3 | 959119-26-7 | 95.0% | 1 MG
Erythromycin-d3 is a deuterium-labeled macrolide antibiotic produced by the actinomycete Streptomyces erythreus. It exhibits broad-spectrum antimicrobial activity by binding to bacterial 50S ribosomal subunits, thereby inhibiting RNA-dependent protein synthesis. Beyond its antibiotic properties, Erythromycin also demonstrates antitumor and neuroprotective effects in various research areas.
- Can be utilized as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC 3-O-methyldopa-d3 hydrate | MFCD11983476 | 232.25 | C10H12D3NO5 | 5 MG
3-O-Methyldopa-d3 hydrate is the deuterium-labeled form of 3-O-methyldopa supplied as a white to off-white solid hydrate. It is designed for use as an internal standard or tracer in quantitative analyses and for research on dopamine metabolism and related neurological disorders.
- Deuterium-labeled internal standard for LC-MS, GC-MS, and NMR.
- Suitable for quantitative tracer and assay development.
- Solid hydrate form with stable isotopic labeling.
- Useful in studies of dopamine metabolism and neurological disease models.
- Supplied in small research-scale quantities for analytical applications.
Medchemexpress LLC Fingolimod-d4 hydrochloride | 1346604-90-7 | 99.0% | 347.96 g/mol | C19H30D4ClNO2 | 5 MG
Fingolimod-d4 hydrochloride is the deuterium-labeled hydrochloride salt of fingolimod provided for research use. It is supplied as a solid with high chemical and isotopic purity, intended as an internal standard or tracer for analytical, pharmacokinetic, and bioanalytical studies. The compound is soluble in DMSO and is stored sealed away from moisture; solvent storage conditions apply.
Medchemexpress LLC D-ribose-13C | 70849-24-0 | MFCD00064325 | 99.9% | 151.12 g/mol | (13C)C4H10O5 | 100 MG
D-ribose-13C is a stable isotope-labeled form of D-ribose supplied as a white to off-white solid for laboratory research. It is used as a positional tracer in metabolic and biochemical studies to follow ribose incorporation and quantify metabolic flux by analytical techniques such as NMR and mass spectrometry. The material is high purity and packaged in small quantities for research-scale experiments.
- 13C-labeled at carbon-1 for positional tracing.
- High purity suitable for analytical applications.
- White to off-white solid form for easy handling and storage.
- Compatible with NMR and mass spectrometry workflows.
- Available in small package sizes for research-scale experiments.
- Intended for research use only; not for human consumption.
Medchemexpress LLC Fluvastatin-d6 sodium | 00-00-0 | 98.1% | C24H19D6FNNaO4 | 10MG
Fluvastatin-d6 sodium is a deuterium-labeled research standard of fluvastatin sodium, intended for use as an internal standard or tracer in mass spectrometry, pharmacokinetic, and metabolic studies. It preserves the biochemical profile of the parent HMG-CoA reductase inhibitor and is supplied at high purity for quantitative and qualitative analyses; for research use only.
- Deuterium-labeled analog for accurate mass spectrometry quantitation.
- High purity (98.1%) for reliable analytical results.
- Molecular formula C24H19D6FNNaO4 supports identity confirmation.
- Suitable as an internal standard in pharmacokinetic and metabolic studies.
- Available in small pack sizes suitable for analytical workflows.
- Supplied for research use only; not for human or clinical use.
Medchemexpress LLC Ethyl octanoate-d15 | 1219798-38-5 | 98.5% | 187.36 | C10H5D15O2 | 50 MG
Ethyl octanoate-d15 is the deuterium-labeled analogue of ethyl octanoate provided for use as a stable-isotope tracer and internal standard in analytical chemistry. It is intended for mass spectrometry, tracer studies, and quantitative analysis where isotopic distinction from the native compound is required.
- Deuterium-labeled (d15) ethyl octanoate for isotopic tracing.
- High chemical purity (98.5%) suitable for analytical use.
- Suitable as an internal standard for mass spectrometry and quantitative analysis.
- Colorless to light yellow liquid with density 0.867 g/cm³.
- Available in small, research-scale quantities (mg-range).
- Certificate of analysis and safety data sheet available.